1,2Davorka Švegar
2 Alma Mater europaea, Maribor, Slovenia
Davorka Švegar
University Hospital center rijeka Krešimirova 42, rijeka, croatia
e-mail: davorka.svegar@gmail.com
Abstract
Some literature reviews have been carried out about the role of perforin in medicine. The first step in- volved a systematic search to identify relevant studies published between 2001 and 2019 in the following electronic databases - ebScohost, Sco- pus, Science direct, Web of Science, and elsevier. by analyzing the available literature, it can be conclud- ed that perforin plays an important role in cytoxical activity of natural killer cells (nK) and cd8+ T cell. nK and cd8+use the same mechanism for destroy- ing target cells. This article cites the disease he- mophagocytic lymphohistiocytosis (HlH) which is characterized by heavy abnormalities in the immune system. The point is that this disease is caused by perforin gene mutation. The key is the application of properly sensitized dendritic cells (dcs) because they are effective in immunotherapy against cancer. it may be effective in γ-irradiated colon cancer cell lines HT-29. growth hormone-inhibiting hormone (giH) induces maturation and activation of dcs. in that way, giH-dcs shows increased cytotoxic activ- ity and higher perforin and granzyme expression. So, this means that theoretical research has shown that efficient activity against cancer is induced when dcs are sensitized with γ-irradiated cancer cells. in that way, through a direct increase of cytotoxicity and indirect T cell activation,there can beanti-tumor ac- tivity. it is suggested to continue scientific research about the role of perforin in the future.